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Additionally, mutations affecting vitamin B 12 transport and intracellular metabolism have been identified (17)

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Stacks are discussed for experimental design only

Therefore, since omeprazole only impairs the absorption of protein bound vitamin B12 from animal-derived dietary sources, the use of free or unbound vitamin B12 (such as cyanocobalamin) are not affected and can be safely used to correct the vitamin B12 deficiency especially if the patient cannot stop taking the omeprazole