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doi:10.1038/s41586-019-0992-y 31

When the autophagy flux is compromised, Nrf2 signaling is activated

Excretable hydrophilic metabolites are usually produced during phase II metabolism by glutathione S-transferases, uridine 5-diphospho (UDP)-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, and epoxide hydrolases