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Plant extracts modulate ferroptosis for the treatment of MIRI Target the amino acid pathway to regulate ferroptosis Britanin (Bri) is a bioactive sesquiterpene lactone isolated from Inula linariifolia and has anti-inflammatory and anti-tumor activities [162]

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The peroxidation of PUFA is primarily mediated by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (Massey and Nicolaou 2011)

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