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It is a multifactorial condition influenced by a complex interplay of genetics, nutrition, disease, medications, physical and chemical damage, and stress ( Anwuligan, a monomeric lignan from forsythia, was recently shown to inhibit non-small-cell lung cancer ( Among the DEGs identified in this study, Dkk4 and Smad6 were altered in both anwuligan-treated mouse skin tissues and HFSCs, while Lgr6 was particularly differentially expressed in anwuligan-treated HFSCs

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FEBS Lett 579:31193125 Mihm MJ, Bauer JA (2002) Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase

Brandizzi F, Barlowe C