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Much less is known about the -Glutamyl di- peptides

Mechanistically, gut microbiota-derived SCFAs exert their functions by activating trans-membrane G-protein-coupled receptors (GPCRs) of GPR41 and GPR43 or inhibiting histone acetylation (HDAC) to directly enter host cells (Moniri and Farah, 2021)

Elevated HMGB1 levels serve as a significant marker of SCZ