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The uptake of pravastatin on its first pass through the liver also provides a potential advantage by keeping the drug out of the systemic circulation, from which it could be taken up by muscle cells and thereby cause toxic effects such as rhabdomyolysis

This inflammation can lead to pigmentation issues, particularly in individuals prone to post-inflammatory hyperpigmentation

Orzechowski A, Schrenk D, Bock-Hennig BS, Bock KW

These residues form hydrophobic interactions with the methyl groups, while the carbonyl O of P124 hydrogen bonds with the nitrogen atom, which conforms to a tetrahedral configuration suggesting that it is protonated