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Clinical Study -55.8% wrinkles 55.8% reduction in wrinkle volume in a 12-week, double-blind, placebo-controlled facial study (71 women)

doi: 10.1016/j.freeradbiomed.2016.02.028 13

the presence of key substrates for peroxidation, i.e., phospholipids with polyunsaturated fatty acyl termini and diallyl carbons that are susceptible to peroxidation [For example, the classical pathway mediated by ALOXs (195) or POR (196) and the non-classical pathway mediated by the peroxisome-ether-phospholipid axis (197) act on the peroxidation of PUFAs] (3)

As expected, GPx3 correlated with GFR and urine output and was low in patients with impaired kidney function