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TH PRKN -mutant DA neurons particularly displayed smaller, functionally compromised mitochondria when compared with TH counterparts, underscoring the mitochondrial vulnerabilities associated with PRKN-linked PD 46

Hematol Am Soc Hematol Educ Program (2005), 8995

Future research must address long-term toxicity profiles, the scalability of nano-manufacturing, and the standardization of regulatory approval pathways for nano-nutraceuticals. To facilitate clinical feasibility, subsequent studies should prioritize the integration of pharmacodynamic biomarkers, quantitative BBB penetration analysis, and rigorous safety profiling to establish standardized clinical dosing strategies

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