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C., Wright, J

A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class

Its documented that BDNF upregulation distinguishes it as a primary nootropic research compound

"Given substances under S0 do not have current approval by any governmental regulatory health authority for human therapeutic use, no TUE (Therapeutic Use Exemption) would be granted under any circumstances." Despite the revealing of Essendon's consent forms - which listed weekly injections of AOD-9604 - the club said it did not prove any player used the substance