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In addition to the cell death modalities mentioned in this review, mitochondria act as direct drivers in multiple contexts: in mitochondrial permeability transition-driven necrosis, the opening of the mitochondrial permeability transition pore leads to loss of membrane potential and energetic collapse, serving as a direct trigger for cell death (Tsujimoto et al., 2006)

CrossRef Endothelial GNAQ p.R183Q mutation confers hemoporfin-mediated photodynamic therapy resistance and drives pathological angiogenesis via the angiopoietin-2/TIE2/PI3K/AKT pathway Lu Liu, Linmei Wang, Jiaxin Luo, Jiayun Yu, Liang Xie, Yang Liu, Hong Xu, Fan Hu, Hanmin Liu Frontiers in Cell and Developmental Biology.2025;[Epub] CrossRef Gold nanoparticle-mediated photothermal therapy: Expanding the frontiers of cancer treatment and theragnostics Mariana Neves Amaral, Pradeep Kumar, Pedro Fasca, Hugo Alexandre Ferreira, Joo M.P