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To make matters more dire, most commercial materials are composed of more than one polymer, adding the complexity of separation of one polymer from another

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At the same time, pro-inflammatory factors (TNF- and IL-1) were downregulated and anti-inflammatory factors (Arg-1 and IL-10) were upregulated due to SIN produced through the NF-B pathway, which decreased M1 macrophage levels and increased M2 macrophage levels