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Ramucirumab and durvalumab for previously treated, advanced non-small-cell lung cancer, gastric/gastro-oesophageal junction adenocarcinoma, or hepatocellular carcinoma: an open-label, phase Ia/b study (JVDJ)

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This may also regulates the activity of several transcription factors to modulate the expression of proteins such as cytoskeletal, cell-cell junctional components, cell cycle regulators and anti-apoptotic effectors

In this process, exons or introns can be either included or excluded from precursor-mRNA resulting in multiple mature mRNA variants