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The physiological jaundice is usually benign, however brain injury and lifelong disability can occur if serum bilirubin (unconjugated), which is neurotoxic, is too high level and crosses the BBB causing damage of auditory nerve and basal ganglia (Subcommittee on Hyperbilirubinemia American Academy of Pediatrics, 2004)

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In addition, female gender, low income, poor parental relationships, singleness, smoking and alcohol abuse, dietary structure, gut microbiota, and other heterogeneous factors have been reported to be related to depression (Milaneschi et al., 2011

Enhanced glutaminolysis in cancer cells ensures a stable supply of glutamate and -KG via sequential deamination processes inside mitochondria