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sinensis was classified as a probable carcinogen (Group 2A) to humans (143, 144)

Caffeine and accumbens shell dopamine

At the 1500 mg/kg dose, at 48 h, rats exhibited rises in circulating liver enzymes, showing a peak serum alanine aminotransferase (ALT) rise 36-fold above vehicle controls and a 33-fold serum aspartate aminotransferase (AST) rise over control (Fig