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Its just that a clinician might not consider a twenty- or thirtysomething to be well-indicated for this particular therapy

AGEs and obesity Dietary and endogenous AGEs and the AGE-RAGE interaction can promote oxidative stress and inflammation, contributing to the accelerated progression of obesity-related complications such as elevated serum AGEs, insulin resistance, AGE accumulation, and elevated proinflammatory cytokines in adipose tissues 67,76 , although consumption of dietary AGEs does not necessarily increase obesity based on its marginal association with increased body weight gain 67,76