what nutrient is a coenzyme for glutathione peroxidase Simplified catalytic mechanism of the peroxidase: in the The glutathione peroxidase family: Discoveries

Cisplatin detoxification by GSH generally occurs by a reaction catalyzed by GST, in which GSH binds covalently to cisplatin and the formed GSH conjugates can be exported from the cells, preventing the drug from reaching its most important molecular target, DNA

Hassanen, E

The trade-off is efficacy: NAC has stronger evidence for raising intracellular glutathione levels than oral glutathione does, precisely because NAC is actually absorbed

Secondly, post-insertion of transgene, non-coding RNAs are generated by host organism against the inserted foreign DNA or from the inserted transgene/construct against the host genes