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10.1021/bi010518v Biochemistry 6 BohrerA.-S.TakahashiH

But results depend on where you get treated

Plant Physiol 97(3):863872

873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway