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In conditions of progressive NAFLD, OS can also result from increased ROS generation due to impairment of mitochondria caused by an overload of FFAs and an increase of their metabolism, lipotoxicity, and hypoxia, as well as ROS production through NADPH-oxidase isoforms associated to ligandreceptor link or by activated inflammatory cells ( Evidences suggest that lipotoxicity mediated by FFAs ( increased endoplasmic reticulum oxidoreduction-1 (ERO-1) activity, the enzyme that catalyzes disulfide bond formation ( 2 O 2 production

Understanding the fundamental role of glutathione in our body sets the stage for exploring how it can influence our sleep quality

The impairment of the acid barrier exposes the intestinal tract to infections with various microorganisms [73] and modifies the gut microbiota, reducing its diversity and promoting the proliferation of oral bacteria in the small intestine [74]

Chronic stress Long-term stress increases oxidative processes in the body, leading to GSH depletion and reduced ability to neutralize harmful molecules