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Additionally, cancer patients often manifest decreased levels of vitamin B6, and it seems that vitamin B6 deficient cancer cells appear to be much more resistant to stress-induced death, e.g., in lung cancer 33 , thus reducing the effects of chemotherapy

Kern et al., 2014)

157,158,159,160,161,162 The effect of PARPs to stimulate chromatin decompaction might be exerted via the steric hindrance of PAR chain, the negative charge of DNA and PAR, or the displacement of core histones

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