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Stress-activated NRF2-MDM2 cascade controls neoplastic progression in pancreas

These chemical groups enable NAC to effectively interact with a wide range of radical and non-radical reactive oxygen and nitrogen species (RONS)

doi: 10.1074/jbc.M110.186999 141 LemK

These diverse phenotypes demonstrate the essential role of endolysosomal zinc homeostasis in maintaining neuronal proteostasis, systemic metal balance and tissue integrity across multiple disease contexts