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2376-0249 Case Blog - International Journal of Clinical & Medical Images (2014) Volume 1, Issue 4 Author(s): Int J Clin Med Imaging 2014 Abstract A 14 year old boy presented with a bathing trunk naevus since birth which progressively showed hypertrichosis, nodularity and areas of lax skin Clinical presentation A 14 year old boy, product of a non-consanguinous marriage and born by normal vaginal delivery presented with history of a circumscribed light brown patch over the back since birth which progressively became darker and increased in size to involve whole of the back, major portion of the chest and abdomen and proximal parts of upper and lower limbs

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Activation of AMPK Pathway: MOTS-c modulates the folate and methionine cycles, increasing intracellular levels of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a potent activator of AMP-activated protein kinase (AMPK)

Firstly, in vitro experiments showed effective killing of CD117 + HSCs and HSPCs from mice