glutathione s-transferase autism

glutathione s-transferase autism An Open-Label Case Series of Use for Symptomatic Management in Children with Spectrum Disorder Redox System Dysfunction as a

Name: glutathione s-transferase autism An Open-Label Case Series of Use for Symptomatic Management in Children with Spectrum Disorder Redox System Dysfunction as a
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Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis Glutathione transferases: substrates, inihibitors and pro drugs in cancer and neurodegenerative diseases Oncogenesis The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta analysis Nutrition & Metabolism Springer Nature Link Oxidative stress response and NRF2 signaling pathway in autism spectrum disorder ScienceDirect

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Description

Chapman, R

Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)