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A recent Nature review describes NAD+ as an essential redox coenzyme and notes that NAD+ and NADH ratios are important for energy generation, metabolic homeostasis, mitochondrial function, and DNA repair

If absorption or intake is an issue, it can be increasingly challenging to meet your daily B12 needs

You may also be more likely to develop vitamin B-12 deficiency if you have: Atrophic gastritis, in which your stomach lining has thinned Pernicious anaemia, which makes it hard for your body to absorb vitamin B12 Conditions that affect your small intestine, such as Crohns disease, celiac disease, bacterial growth, or a parasite Immune system disorders, such as Graves disease or lupus Been taking certain medications that interfere with the absorption of B12

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