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For instance, In June 2021, according to the news release published by Elsevier, off-target toxicities are a major cause of dose-limiting side effects in antibody-drug conjugates (ADCs), primarily due to linker-drug instability and premature payload release

The same group subsequently reported that BPC-157 modulates vasomotor tone by enhancing phosphorylation of Src, caveolin-1, and eNOS, and that the peptide reduces caveolin-1/eNOS binding a step that releases eNOS from caveolar inhibition and permits nitric oxide generation (Hsieh et al., 2020)

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