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Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents

2 BioMed Research International (PubMed)GHK-Cu chemistry: glycyl-L-histidyl-L-lysine copper complex and copper transport

This increase in the GPxs and Prxs activity means that there is a synergetic coupling among GPxs, Prxs and other antioxidants

The body naturally possesses a ferroptosis defense system to protect cells, which primarily includes 1) Cystine/System Xc/GSH/GPX4, 2) FSP1-CoQ10-NAD(P)H, 3) DHODH-CoQ10-CoQH2, 4) GCH1/BH4/DHFR, and 5) FSP1/ESCRT-III (Wang et al., 2023)