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Additionally, frequent use of alcohol as a sleep aid leads to tolerance, with its sedative effects waning within about a week of repeated use

The downstream pathway of Nrf2, on the other hand, involves inhibitory effects on oxidative stress, inflammation and apoptosis, including but not limited to several important protein molecules, such as HO-1, SOD, MDA, TNF-, ILs, the caspase family of proteins, Bcl-2 and Bax