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Enhancing the efficiency and specificity of a genetic vaccine nucleic acid uptake by a given cell type by coating the nucleic acid with an evolved protein that binds to the genetic vaccine nucleic acid, and is also capable of binding to the target cell In one embodiment, the invention provides methods of enhancing the efficiency and specificity of a genetic vaccine nucleic acid uptake by a given cell type by coating the nucleic acid with an evolved protein that binds to the genetic vaccine nucleic acid, and is also capable of binding to the target cell

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When an equimolar concentration of Cu(II) was added to the equimolar mixture of normal 2M and HSA, almost all copper was eluted in a single peak corresponding to CuHSA, demonstrating that 2M cannot compete for Cu(II) ions with HSA even at equimolar concentration (Fig