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Wisegrade is a plant- based GMCSF (granulocyte-macrophage colony-stimulating factor) glycoprotein that is shown to react with melanocyte receptors, activating multiple MITF (microphthalmia-associated transcription factor) pathways inducing melanogenesis and stem cell protection

J., Manley-Harris M., Wilkins A

Its hallmark pathological features including cartilage degradation, subchondral bone sclerosis, osteophyte formation and synovial inflammation, are fueled by a complex interplay of inflammatory cascades, oxidative stress, and mechanical stress imbalance (57)

However, treatment with the aqueous lyophilisate of F