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In response to LPS, there was significant NF-B signal transduction pathway enrichment in LKO cholangiocytes with increases in several chemokines such as Cxcl2 (8-fold increase) and Cxcl5 (128-fold increase) as well as the proposed BA diagnostic chemokine Mmp7 (9-fold increase)

5 Non-mast cell sources of histamine may also include basophils and neutrophils

The aim to improve the effect of metformin led to the development of phenformin 43 , which showed an improved cellular uptake compared to metformin 44