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4.2.2 Vitamin B1: thiamine Vitamin B1, as a central regulator of energy metabolism, directly facilitates mitochondrial ATP production by catalyzing the activities of -ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes in the tricarboxylic acid (TCA) cycle through its active form, thiamine pyrophosphate (TPP) (41)

Data analysis The Comprehensive Meta-analysis software was utilized to process the data extracted from the included studies

In our correlation of metabolite-gene pairs, we found that LPC 22:5 and many VLCFA and their hydroxy derivatives were positively correlated to the expression of KDM4D, DTX3 , and NOTCH4 , and negatively correlated with the expression of MT_TS1

In mice, a GCLC deficiency leads to embryonic death (Maher 2006)