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Patient-centred strategies must identify patients tumour, current and planned conventional therapies (chemotherapy, endocrine therapy, targeted therapy and immunotherapy), comorbidities, organ function, nutrition profile, dietary habits and existing medication or supplement use since these factors critically impact both the efficacy and safety of supplementary approaches (236)

Furthermore, ROS interacts with cellular transduction pathways like protein kinase C/extracellular signal-regulated kinases (ERK)/mitogen-activated protein kinase (MAPK) pathway that can affect cell growth, cell proliferation, differentiation, apoptosis and gene expression [10, 11]

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Frasier CR, Moukdar F, Patel HD, et al