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10.1038/nature07813 Nature 16 ChaudhariA.GuptaR.PatelS.VelingkaarN.KondratovR

Previous studies have reported that Nrf2 deficient mice developed vacuolar (spongiform) leukoencephalopathy along with extensive astrogliosis, revealing a possible physiological role for Nrf2 in maintaining myelin in the central nervous system (Hubbs et al., 2007)