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Formation of ROS is likely followed by generation of hydroxyl radicals according to the Fenton's reaction: because traces of catalytic iron ions can easily be released from the needle during the injection

10.1128/AEM.70.4.2494-2496.2004 Appl

Drug Chem Toxicol 46:357368 Hassanen EI, Tohamy A, Issa MY, Ibrahim MA, Farroh KY, Hassan AM (2019) Pomegranate juice diminishes the mitochondria-dependent cell death and NF-kB signaling pathway induced by copper oxide nanoparticles on liver and kidneys of rats