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Description

Similar to PROTAC 51 , PROTAC 52 exhibits robust cytotoxic activity against several FLT3-ITD mutant AML cells (IC 50 = 1.66 nM) by inducing a marked UPS-dependent degradation of the FLT3-ITD protein (DC 50 = 41.35 nM)

It is well known that CNS trauma and infection are accompanied by widespread inflammation in the brain and resident glial cells, including astrocytes and microglia, play a key role in the initiation and propagation of this response (Corrigan et al., 2016)