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Nuclear defects : Congenital dyserythropoietic anemia (CDA) has been attributed to defects in nuclear maturation or division in human patients

[DOI] [PubMed] [Google Scholar] 61.Allwood E.M., Logue C.-A., Hafner G.J., Ketheesan N., Norton R.E., Peak I.R., Beacham I.R

10.1176/appi.ajp.2007.07010042 54

Further structural optimization delivered a large number of macrocyclic disulfides and among them 23 (HA08) encompassing a 3-homotyrosine residue in a 13-membered ring system and exhibiting the lowest Ki value in the series (Ki = 3.3 nM)