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For CCS this may be facilitated by Mia40 anchored to the inner mitochondrial membrane, as Mia40 reduction mediates CCS disulfide bond formation.[ 79 , 80 ] Mia40 is reoxidised by Erv1, which donates an electron to cytochrome c for use in the electron transport chain, and downregulation of Erv1 is associated with decreased mitochondrial SOD1 import

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Because the brain consumes a large amount of oxygen and leads to high production of reactive oxygen species, the antioxidative capacity of glutathione is important to keep brain homeostasis

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