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(2011) 127:78794.e1-9

The reaction with 2-eq of appropriate alcohols with either POC13 or 4- nitrophenyl phosphorodichloridate provides intermediate A14, which is then used to derivatize the phenolic hydroxyl of A2 to provide a desired product, A15

Rapid developments in omics technologies provide an opportunity of thoroughly evaluating disease models on a global scale and exploring their relevance by comparisons with human data 29,30,31