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Thus, it was shown that vitamin C increases the expression of genes associated with dopaminergic differentiation by inducing the demethylation of DNA and histone 3 (H3K27m3) in the promoter region of genes involved in neurogenesis, differentiation and neurotransmission, an effect mediated by Tet1 and Jmjd3 demethylases, respectively (Wu et al., 2014)

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