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doi: 10.3389/fendo.2020.00591 17 YamazakiYKanekiyoT

10.1126/science.aac9462 54 JonasP.BurnashevN

41 DenisonT.MorrellM

Mitochondrial-mediated apoptotic pathways are activated in both malignant clones and sensitive normal compartments (e.g., intestinal crypt stem cells, granulocyte-macrophage progenitors), driving dose-limiting gastrointestinal and myelosuppressive toxicities ( 3.2 Death receptor-induced apoptosis as a promising anticancer modality Genetic studies indicate that apoptosis triggered by TNFR family death receptors is pivotal in conferring resistance to chemotherapeutic agents (Sartore-Bianchi et al., 2016)