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Moreover, experiments are often performed under supraphysiological pressures [47,48,49] that are orders of magnitude larger than those sensed by tumor cells in vivo

Inflammatory cytokines and enzymes, such as interleukin-6 (IL-6), interleukin-17 (IL-17), tumor necrosis factor-alpha (TNF-), nitric oxide (NO), inducible nitric oxide synthase (iNOS), and matrix metalloproteinases (MMPs), show a high correlation with the pathogenesis of hemorrhoids