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Borgstrm and colleagues (1986) reported oral NAC bioavailability in the range of 4 to 10%

Peter B, Kanyo N, Kovacs KD, Kovacs V, Szekacs I, Pecz B, Molnar K, Nakanishi H, Lagzi I, Horvath R

doi: 10.1146/annurev-micro-032521-015858 61 ChowdharyA.MeisJ

A similar approach was used to open and close human acid-sensing ion channels (ASICs), which are also trimers but are unrelated in sequence to P2X receptors