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At doses of 1.0 and 5.0 ng/ml of rTGF 1, which are physiologically relevant levels in mice, 25 there were significant increases in BBB permeability (Figure 2b)

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Perioperative implications were evaluated with emphasis on orthopaedic surgical risk domains relevant to total joint arthroplasty (TJA), including wound complications, hematoma formation, immune modulation, infection susceptibility, heterotopic ossification, and implant fixation considerations

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