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(D and E) Reproduced with permission Copyright 2018, ACS Omega [126]

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This change triggers the endothelial cell apoptosis, vessel regression, and blood flow reduction in the CL ( 3 Epigenetic regulation of corpus luteum function In addition to genetic and signaling pathways, epigenetic mechanisms act as key integrators of hormonal and metabolic signals, ensuring coordinated regulation of corpus luteum function

These tissues rely heavily on consistent mitochondrial activity to maintain electrical signaling, muscle contraction, and metabolic stability