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Rymbai E., Sugumar D., Chakkittukandiyil A., et al., The Identification of Cianidanol as a Selective Estrogen Receptor Beta Agonist and Evaluation of Its Neuroprotective Effects on Parkinson's disease Models, Life Sciences 333 (2023): 122144

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Because N-acetylation is a minor pathway of drug metabolism, pharmacogenetics remained of largely academic interest until the late 1970s, when it was found that the cytochrome P450 isoenzyme CYP2D6, which is involved in the phase 1 metabolism of 2025% of all drugs, showed functionally important genetic polymorphisms