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Specifically, BDNF contains sorting motifs in the pro domain region and mature region that can interact with the sorting receptors CPE and sortilin [9, 41, 53]

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An altered mitochondrial Ca 2+ buffering may lead to prolonged elevation of intracellular Ca 2+ levels, activating various enzymes that can damage cellular structures and contribute to the inflammatory response

Notably, co-incubation with MELNs reduced oxidative stress levels, underscoring MELNs protective effect on insulin-resistant hepatocytes