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Ultrasound-assisted extraction (UAE) employs acoustic cavitation to disrupt cell walls, improving solvent penetration and enhancing extraction efficiency

GluN2A and GluN2B dominate in the mammalian higher brain structures such as the cortex, and it is well known that there is a developmental switch for NMDAR GluN2 subunits during postnatal development [6], which leads to a change of NMDAR subunit composition from GluN2B to GluN2A subunit-dominant receptors in most brain regions including the cortex, particularly at synapses

show coherence and consistency across animal models, which lends additional confidence in findings (117)

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