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Additionally, in patients with folic acid deficiency, the plasma levels of methionine and betaine remain unchanged, and the DMG concentration increases, which suggests that betaine, acting as a methyl-group donor, is able to compensate for folic acid deficiencies and ensure the proper functioning of the one-carbon cycle [202,203]

Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability

Evans, K

The inhibitor of glutamine synthetase (GS) activity, l-methionine sulfoximine (MSO), has been shown to inhibit glutamine metabolism, induce a shift to M1-TAMs, and act as a potent antitumor immunity [123]