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Disruption of protein homeostasis is recognized as a hallmark of aging [70], and previous studies have shown that impaired ovarian angiogenesis and vascular remodeling contribute to inadequate follicular development and ovarian aging [71]

Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS (2007) Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

However, when the cellular iron content is low, this interaction is inhibited, stabilizing NCOA4, which in turn increases ferritinophagic flux and iron release in lysosomes (78)