El Sayegh TY, Kapus A, McCulloch CA
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection
doi: 10.1007/s13402-023-00831-8 187 LiuJLiuHLiuHTengYQinNRenXet al
Furthermore, the redox system not only involves redox-associated enzymes, such as the glutathione biosynthesis pathway, GPXs, GR, catalase, superoxide dismutase (SOD), and NOXs, but also intertwines with glucose metabolism, fatty acid oxidation, and mitochondrial function for the generation of reducing equivalent NADPH, with glutamine metabolism for the supplement of glutamate for glutathione synthesis, and with other signaling pathways including NRF2-mediated upregulation of the antioxidant system for a better adaptation to oxidative stress
