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Al-Zaidy SA, Sahenk Z, Rodino-Klapac LR, Kaspar B, Mendell JR

Their secretion of matrix metalloproteinases (MMPs), serine proteases, and cathepsins disrupts the endothelial basement membranes, degrades extracellular matrix components, including collagen, and facilitates the migration of tumor and stromal cells, ultimately promoting tumor angiogenesis and metastasis ( Dixon defined ferroptosis as a unique type of controlled cell death in 2012, based on its iron-dependent mechanism and fundamental deviations from apoptotic pathways ( Figure 3 )

& Gottardi, C

Quantitative assays are also recommended for those with abnormal or equivocal qualitative assay results so as to verify the diagnosis